麻豆淫院

(麻豆淫院Org.com) -- Imagine the wealth of information that would be at our fingertips if we could understand the genetic basis and evolutionary history that underlies the vast diversity in form and function seen within mammals.

An international collaboration including Conway Fellow, Dr Emma Teeling has created a phylogenetic framework using large genetic datasets to better understand the evolutionary history of mammalian families and the role of the environment and events in earth history in promoting living biodiversity.

Recently published in the journal Science, the findings of the Tree of Life consortium are the culmination of a five year project led by scientists at the University of California, Riverside (Prof. Mark Springer) and Texas A&M, USA (Prof. William Murphy). The study generated the largest DNA sequence alignment from more than 99% of mammalian families to build evolutionary trees that depict how different groups of mammals are related to each other and when they diverged from each other.

Dr Emma Teeling鈥檚 research group, a Science Foundation Ireland funded team and members of the Tree of Life consortium, produced the majority of bat data in the project.

Explaining how the team produced reliable time estimates of when different mammal groups split, she said, 鈥淲e used a 鈥榬elaxed clock鈥� approach that enables rates of DNA to change across the tree of mammals. We used a large collection of well established fossil mammals to estimate rates of change on different branches of the tree. This allowed us to convert the phylogentic tree of evolutionary relationships into a time-tree, in which the branches are scaled in proportion to time.

Using the time-tree, we were able to examine when different groups of mammals originated and diversified, and then associate factors that might have been responsible for these diversification events. For example, we observed a distinct pulse of diversification near the end of the Cretaceous Terrestrial Revolution (80-82 million years ago) when flowering plants started to diversify and when most of the mammalian orders began diverging from one another鈥�.

This phylogeny also serves as a framework to understand the history of the unique changes in the genome underlying the vast morphological diversity observed in more than 5400 living species of mammals.

Co-lead author on the publication, Professor Mark Springer from the University of California, Riverside said, 鈥淲hen you understand how taxa are related to each other... you can pinpoint key molecular changes that are associated with key morphological changes鈥�.

For Emma Teeling鈥檚 research, this equates to changes at genomic level underpinning morphological and molecular changes associated with flight and echolocation in bats. 鈥淚 personally will use this phylogeny to explore in more detail the evolution and genetic control of vision and hearing and how this relates to human disease鈥�, she said.

She is excited about the possibilities that the framework offers biologists for comparative research in biomedicine, physiology and immunology. 鈥淎lthough the Tree of Life is currently a work in progress, it provides a benchmark that we can use into the future to decipher how our genome functions and has evolved鈥�.