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A fresh look inside the protein nano-machines

Proteins digest food, and fight infections and cancer, and serve other metabolic functions. They are basically nano-machines, each one designed to perform a specific task. But how did they evolve to match those needs, and how did genes encode the structure and function of proteins? Researchers from the University of Geneva (UNIGE), Switzerland, the Institute for Basic Science, Korea, and the Rockefeller University, U.S., have conducted a study that tackles this question and explains the basic geometry of the gene-to-protein code by connecting proteins to properties of amorphous physical matter.

The full article appears in Â鶹ÒùÔºical Review X.

A protein is a chain made of 20 different kinds of amino acid with elaborate interactions, and unlike standard physical matter, proteins are selected by evolution. "The blueprint for protein synthesis is written in long DNA genes, but we show that only a small fraction of this huge information space is used to make the functional protein," explains Jean-Pierre Eckmann, Professor at the Department of Theoretical Â鶹ÒùÔºics from the Faculty of Science of UNIGE.

Together with Prof. Tsvi Tlusty from the Center for Soft and Living Matter, Institute for Basic Science (IBS) in Korea and Prof. Albert Libchaber from the Rockefeller University in New York, Prof. Eckmann shows that the only changes in the code that matter are those occurring in the segment of the gene coding the mechanically relevant hinges of the nano-machine. The changes in other regions of this highly redundant code have no impact. "We are now using this new approach to understand the relation between the function and dynamics of several important proteins."