麻豆淫院

The nervous system is essential for coordinating the organismal stress response. Neurons with mitochondrial stresses could release signals and communicate with the peripheral tissues to activate the organismal-wide mitochondrial unfolded protein response (UPR^mt) for fitness adaptation.

G-protein-coupled receptors (GPCRs) play important role in transmitting various extracellular signals into cells, and have been considered one of the largest families of validated drug targets. However, whether GPCR signaling is required for coordinating inter-tissue mitochondrial stress communication remains largely unknown.

Dr. Tian Ye's group from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences (CAS) revealed that GPCR signaling is critical for coordinating the intestinal UPR^mt activation in response to neuronal mitochondrial perturbations in Caenorhabditis elegans.

In this study, the researchers identified that a GPCR SRZ-75 is expressed in a pair of ADL neurons (amphid neurons with dual ciliated sensory endings) and mediates the neuronal-to-intestinal UPR^mt communication. SRZ-75 couples with its downstream G伪q signaling to promote the release of neuropeptides from ADL neurons to propagate the cell non-autonomous mitochondrial stress activation.

According to the researchers, ablation of ADL neurons strongly attenuated the intestinal UPR^mt activation in response to neuronal mitochondrial stresses. Enhanced GPCR/SRZ-75-G伪q signaling in ADL neurons induced the intestinal UPR^mt activation and subsequently enhanced host resistance to Pseudomonas aeruginosa (PA14).

In addition, enhanced ADL-GPCR SRZ-75-G伪q signaling also improved proteostasis, altered mitochondrial morphology, and changed lipid metabolism in peripheral tissues.

In summary, this work provides mechanistic insights into neuronal GPCR signaling coordinating the systemic mitochondrial stress response. More importantly, activation of GPCR and downstream signaling in just two ADL neurons altered various distinct physiological characteristics in distal tissues, including an altered metabolic state, improved proteostasis and increased stress resistance.

This cover study entitled "Two sensory neurons coordinate the systemic mitochondrial stress response via GPCR signaling in C. elegans" was published online in Developmental Cell on October 28.