麻豆淫院

Researchers at University of Tsukuba, Osaka University, and Kitasato University developed a novel amide cyclodextrin (cyclic oligosaccharide) that can selectively capture phosphate ions in water. In addition, the researchers revealed the mechanism by which this cyclic molecule captures phosphate in harmony with water molecules.

This investigation helps elucidate the interaction between water molecules and substances in a water-based environment. It can thus lead to the development of materials that function efficiently in an aqueous environment. The research is in the journal Chemical Science.

Cyclic molecules are used in a wide range of applications, including molecular sensing, because they can incorporate specific molecules of interest into their inner cavities. Particularly, the ability to precisely recognize and capture specific molecules in water is critical for drug development and environmental analysis.

Cyclic molecules typically employ hydrogen bonding to capture molecules, whereby neighboring molecules are attracted to each other via functional groups bearing hydrogen atoms. However, water molecules present competition for the hydrogen bonding sites, making it challenging to develop cyclic molecules that can recognize target molecules for hydrogen bonding in aqueous systems.

In this project, the researchers developed a new cyclic molecule that achieves precise molecular recognition through hydrogen bonding in harmony with water molecules. Specifically, a novel cyclodextrin (cyclic oligosaccharide) was synthesized with numerous amide groups (-CONH-) that act as hydrogen bonding units. This molecule shows excellent selectivity for target molecules in water, whereby it traps phosphate, but not sulfate or carboxylate species.

The detailed mechanism by which this cyclic molecule selectively traps phosphate species through multi-point hydrogen bonding in harmony with water molecules was elucidated using nuclear magnetic resonance (NMR) spectroscopy, isothermal titration thermometry (ITC), and molecular dynamic (MD) simulations.

The findings of this study provide guidelines to design new cyclic molecules, while elucidating the interaction between water molecules and other substances. Therefore, it is significant for the development of materials that function in an aqueous environment.