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Machinery behind bacterial nanowires discovered

Machinery behind bacterial nanowires discovered
Bacteria nanowires. Credit: Yale University

Almost all living things breathe oxygen to eliminate the excess electrons produced when nutrients are converted into energy. However, most microbes that mitigate pollution and climate change don't have access to oxygen. Instead, these bacteria—buried underground or living deep under the oceans—have developed a way to eliminate electrons by "breathing minerals" from the soil through tiny protein filaments called nanowires.

In previous research, a team led by Nikhil Malvankar, Associate Professor of Molecular Biophysics and Biochemistry at Yale's Microbial Sciences Institute, showed that nanowires are made up of a chain of heme molecules, just like hemoglobin in our blood, thrust into the environment to move electrons. To leverage the power of these , however, scientists need to know how those nanowires are assembled.

The Yale team led by Cong Shen has now discovered the machinery that assembles the nanowires, making practical applications possible. Of the 111 heme proteins, only three are known to polymerize to become nanowires.

The research is in the journal Cell Chemical Biology.

Not only did the team identify the surrounding machinery that makes it possible for these proteins to become , but they also demonstrated that changing some of the machinery's components can accelerate nanowire reproduction and . This is an important next step in engineering bacteria to efficiently produce electricity, clean pollutants from water, and lower atmospheric methane levels.

More information: Cong Shen et al, A widespread and ancient bacterial machinery assembles cytochrome OmcS nanowires essential for extracellular electron transfer, Cell Chemical Biology (2025).

Journal information: Cell Chemical Biology

Provided by Yale University

Citation: Machinery behind bacterial nanowires discovered (2025, January 17) retrieved 10 September 2025 from /news/2025-01-machinery-bacterial-nanowires.html
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