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March 5, 2025

Innovations in core-shell nanoparticles advance drug delivery and precision medicine

Core–shell NP mechanism for drug delivery. NP, nanoparticle. Credit: OMICS: A Journal of Integrative Biology (2025). DOI: 10.1089/omi.2024.0182
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Core–shell NP mechanism for drug delivery. NP, nanoparticle. Credit: OMICS: A Journal of Integrative Biology (2025). DOI: 10.1089/omi.2024.0182

A review in OMICS: A Journal of Integrative Biology how core-shell nanoparticles could revolutionize drug delivery systems and play a key role in advancing personalized and precision medicine.

Suren A. Ramadhan, from Knowledge University in Erbil, Iraq, and Diyar S. Ali, from Knowledge University and Salahaddin University-Erbil, describe the benefits of core-shell nanoparticles, which provide effective drug encapsulation, shielding the drug from degradation and allowing for controlled release.

"By enabling targeted drug release, this controlled mechanism can help improve treatment outcomes and reduce side effects," stated the authors.

Various materials, including polymers, lipids, and inorganic substances, can be used to create these nanoparticles, and these materials can be tailored for better drug loading, compatibility with the host organism, and specific chemical properties to suit different therapeutic needs.

"This innovation analysis highlights the emerging convergence of nanotechnology with precision/ by unpacking the advances in drug delivery being enabled by core-shell nanoparticles," says Vural Özdemir, MD, MSc, Ph.D., DABCP, MA, Editor-in-Chief of OMICS.

More information: Suren A. Ramadhan et al, Innovations in Core–Shell Nanoparticles: Advancing Drug Delivery Solutions and Precision Medicine, OMICS: A Journal of Integrative Biology (2025).

Provided by Mary Ann Liebert, Inc

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Core-shell nanoparticles are poised to transform drug delivery systems and enhance personalized medicine by offering effective drug encapsulation, protection from degradation, and controlled release. These nanoparticles can be crafted from various materials like polymers, lipids, and inorganic substances, allowing for tailored drug loading and compatibility. This innovation supports targeted drug release, potentially improving treatment outcomes and minimizing side effects.

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