/ en-us Â鶹ÒùÔº internet news portal provides the latest news on science including: Â鶹ÒùÔºics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine. Programmed cell death serves as a critical defense mechanism during viral infection. The kinases RIPK1 and RIPK3, central regulators of programmed cell death pathways, undergo precise modulation through various post-translational modifications. The ADP-ribosylation of RIPK1/3 has been documented, but the functional consequences of this modification on kinase activity and downstream cell death signaling remain elusive. /news/2025-06-reveal-mechanism-parp12-cell-death.html Cell & Microbiology Thu, 12 Jun 2025 13:12:02 EDT news668952721 A unique web-based resource of Daphnia, a sentinel species for environmental pollution, commonly used to help us detect and understand the potential toxic effects of chemicals in the environment, has just been established by Penn State researchers. /news/2025-01-access-daphnia-atlas-view-sentinel.html Environment Mon, 13 Jan 2025 15:39:36 EST news656005173 The National Veterinary Research Institute in Poland reports the first molecular detection of Sarcocystis miescheriana in a condemned pig carcass in that country. The research confirms only the fourth known occurrence of visible cystic lesions caused by sarcocystosis in domestic pigs worldwide. /news/2025-01-fourth-global-protozoan-parasite-pigs.html Veterinary medicine Agriculture Mon, 06 Jan 2025 16:00:01 EST news655401345 University of Pittsburgh researchers have identified evidence of H5N1 adaptation in domestic cats. Work centered on a rural outbreak in South Dakota, where multiple cats died after showing neurological and respiratory symptoms. /news/2024-12-south-dakota-outbreak-reveals-potential.html Molecular & Computational biology Veterinary medicine Thu, 12 Dec 2024 15:34:11 EST news653240044 The results of a study into whether cancer detection dogs can smell bladder cancer in other dogs' urine suggests that this could be an effective new way to diagnose the disease in dogs. The research, involving University of Bristol researchers, is published in Veterinary and Comparative Oncology. /news/2024-12-dogs-cancer.html Plants & Animals Veterinary medicine Fri, 06 Dec 2024 11:44:20 EST news652707856 Researchers with the global Human Cell Atlas (HCA) consortium report significant progress in their quest for a better understanding of the cells of the human body in health and disease, with the publication on 20 November of a collection of more than 40 papers in Nature and other Nature Portfolio journals. /news/2024-11-human-cell-atlas-body.html Cell & Microbiology Molecular & Computational biology Wed, 20 Nov 2024 11:00:01 EST news651318783 For hundreds of years, the clarity and magnification of microscopes were ultimately limited by the physical properties of their optical lenses. Microscope makers pushed those boundaries by making increasingly complicated and expensive stacks of lens elements. Still, scientists had to decide between high resolution and a small field of view on the one hand or low resolution and a large field of view on the other. /news/2024-06-microscopy-technique-route-crisp-images.html Optics & Photonics Fri, 28 Jun 2024 13:28:22 EDT news638800097 Biological processes are framed by the context they take place in. A new tool developed by the Stegle Group from EMBL Heidelberg and the German Cancer Research Center (DKFZ) helps put molecular biology research findings in a better context of cellular surroundings, by integrating different forms of spatial data. /news/2024-04-universal-framework-spatial-biology.html Cell & Microbiology Molecular & Computational biology Tue, 23 Apr 2024 12:06:05 EDT news633092762 Cadmium (Cd) can accumulate in the food chain, with serious impacts on human health and safety. Microplastics (MPs) such as low density polyethylene (LDPE) should be considered not only as a single pollutant but also as a carrier of other pollutants. /news/2024-04-density-polyethylene-microplastics-partially-alleviate.html Ecology Agriculture Fri, 12 Apr 2024 12:36:54 EDT news632144212 A nanoemulsion containing particles of curcumin, which is known to have anti-inflammatory and antioxidant properties, has been found capable of modulating the gut microbiota of mice with intestinal inflammation in experiments conducted by researchers at the University of Western São Paulo (UNOESTE) and São Paulo State University (UNESP) in Brazil. /news/2024-03-curcumin-nanoemulsion-treatment-intestinal-inflammation.html Bio & Medicine Thu, 07 Mar 2024 15:15:03 EST news629046901 A novel therapeutic strategy developed by researchers at São Paulo State University (UNESP) could revolutionize the treatment of visceral leishmaniasis, a neglected tropical disease (NTD) transmitted by sandflies. Some 12 million people suffer from the disease worldwide, and 700,000 to 1 million new cases of occur annually, according to the World Health Organization (WHO). /news/2024-02-nanoparticles-natural-substance-visceral-leishmaniasis.html Bio & Medicine Tue, 20 Feb 2024 13:12:03 EST news627657121 On 18 July 2023, 97 pilot whales became stranded near Albany, WA. /news/2023-08-mystery-mass-whale-strandings.html Plants & Animals Ecology Fri, 18 Aug 2023 12:09:04 EDT news611579341 A research group led by Dr. Tomoaki Murakami from the Tokyo University of Agriculture and Technology has revealed that fibrinogen Aα-chain amyloidosis, a previously unreported disease in animals other than humans, is highly prevalent in Japanese squirrels (Sciurus lis). In this study, they compared the pathology with that of humans, and suggested the importance of Japanese squirrels in the comparative pathological analysis of fibrinogen Aα-chain amyloidosis. /news/2023-08-japanese-squirrels-human-hereditary-diseases.html Molecular & Computational biology Veterinary medicine Fri, 18 Aug 2023 10:51:04 EDT news611574662 Using new gene mapping methods, researchers have found connections between atopic dermatitis (eczema) in dogs and several regions of the genome. Some of the genes identified coincide with genes linked to similar problems in humans. The filaggrin gene region, for example, which is regarded as the most powerful risk factor for atopic eczema in humans, has now also been linked to this disease in Labrador retrievers. /news/2022-12-atopic-dermatitis-dogs-linked-genome.html Molecular & Computational biology Veterinary medicine Fri, 09 Dec 2022 13:36:03 EST news589815361 A team of scientists, led by Xiling Shen, Ph.D., Chief Scientific Officer, and Professor at the Terasaki Institute for Biomedical Innovation (TIBI), has reached new levels in patient model development. They have developed improved methods for generating micro-organospheres (MOS) and have shown that these MOS have superior capabilities for a variety of clinical uses. As documented in a recent publication in Stem Cell Reports, their MOS can be used as patient avatars for studies involving direct viral infection, immune cell penetration and high-throughput therapeutic drug screening, something that is not obtainable with conventional patient-derived models. /news/2022-08-patient-avatars-possibilities-micro-organospheres.html Bio & Medicine Thu, 18 Aug 2022 16:34:03 EDT news580059241 It is now possible to deliver therapeutics based on short interfering RNAs to hepatocytes; however, new delivery solutions are necessary to target additional organs. In a new report now published in Nature Biotechnology, a team of researchers including Kirk M. Brown, Jayaprakash K. Nair, and Maja M. Manas, led by Vasant Jadhav at Alnylam Pharmaceuticals Cambridge MA, U.S., discussed the safe conjugation of 2'-O-hexadecyl (C16) to small interfering RNAs (siRNAs) for potent and durable silencing in target organs of rodents and non-human primates, with broad cell specificity. The experiments delivered sustained RNA interference activity for at least three months. The team observed intravitreal and intranasal administration, which relied on potent and durable knockdown. They investigated the preclinical efficacy of the siRNA targeting amyloid precursor protein via intracerebroventricular dosing in a mouse model of Alzheimer's disease, which ameliorated physiological and behavioral defects of the disease. The team showed the safety of C16 conjugation of siRNAs for therapeutic silencing of target genes outside the liver. /news/2022-06-rna-rnai-therapeutics-lab-clinic.html Biotechnology Molecular & Computational biology Mon, 20 Jun 2022 09:40:02 EDT news574934961 The colon might be the last place people would consider getting a tattoo, but endoscopic tattooing is an important medical technique for marking colorectal lesions for surgery or follow-up. Today, scientists report a next-generation ink for these markings that diffuses less and is more biocompatible than existing inks. The new formulation could make it easier to identify and remove complex colonic polyps and tumors, the researchers say. /news/2022-03-ink-colon-tattoos.html Materials Science Tue, 22 Mar 2022 05:00:03 EDT news567141951 Decabromodiphenyl ethane (DBDPE) has increasingly been used as an alternative to decabrominated diphenyl ether (BDE209) in consumer products such as plastics, textiles, furniture, and electric/electronic devices. The potential target tissues and toxic effects of DBDPE in aquatic organisms remain largely unknown at present, despite its widespread detection in various environments and biotic mediums. /news/2022-02-decabromodiphenyl-ethane-female-zebrafish-primarily.html Molecular & Computational biology Wed, 16 Feb 2022 12:08:58 EST news564235735 A critically endangered Sumatran orangutan in New Orleans has given birth to a healthy male baby, but his twin brother died in the womb, officials at the Audubon Zoo said Monday. /news/2021-12-endangered-orangutan-orleans-healthy-baby.html Plants & Animals Tue, 28 Dec 2021 05:47:36 EST news559892835 Researchers have developed a way to produce high-resolution virtual microscopy images that allow detailed visualization of tissue without time-consuming staining procedures. This approach is an important step toward the ability to perform histopathology analysis during surgery, rather than waiting days for results. /news/2021-11-virtual-histology-approach-groundwork-tissue.html Optics & Photonics Wed, 17 Nov 2021 07:36:24 EST news556356981 Cancer diagnosis is confirmed through histopathology by removing a part of the tissue in question after conducting imaging tests such as MRI, CT, ultrasound, or endoscopy. Based on this clinical diagnosis, the cancerous tissue is surgically removed and suspected tissues or lymph nodes are additionally examined. Future treatment plans, chemotherapy, and radiation are formulated based on these results. Recently, a research team led by POSTECH and Gachon University College of Medicine has developed a machine learning-based histopathology method. /news/2021-11-label-free-intraoperative-histopathology-surgical-specimen.html Optics & Photonics Mon, 01 Nov 2021 10:29:46 EDT news554981383 Amyloidosis is a multifaceted disease group caused by deposits of the misfolded "amyloid" protein in various tissues. Amyloid protein is very unique compared to other native proteins in that it has a cross-β-sheet structure, which gives it distinctive properties, such as resistance to digestive proteinases and transmissibility through ingestion. /news/2021-10-fast-easy-amyloid-fluorescence-fingerprinting.html Veterinary medicine Thu, 07 Oct 2021 12:32:45 EDT news552828762 Histology is the study of biological tissues at a microscopic level. Also called microscopic anatomy, histology is widely used to provide diagnosis of cancer and other diseases. For example, tissue samples obtained during surgery might help to determine whether further surgical action is needed, and further surgery may be avoided if a diagnosis can be rapidly obtained during an operation. /news/2021-04-holographic-histopathology-enables-fast-precise.html Optics & Photonics Fri, 30 Apr 2021 13:04:57 EDT news539006694 Researchers have developed a new intravascular imaging technique that could one day be used to detect coronary plaques that are likely to lead to a heart attack. Heart attacks are often triggered when an unstable plaque ruptures and then blocks a major artery that carries blood and oxygen to the heart. /news/2021-03-imaging-technology-heart.html Optics & Photonics Tue, 16 Mar 2021 13:42:03 EDT news535120917 Lanthanide-doped inorganic upconversion nanocrystals (UCNCs) are attracting more attention, as they are potential fluorescent diagnostic and therapeutic agents for in vivo applications including biological imaging and disease theragnostics. /news/2021-01-biodegradable-inorganic-upconversion-nanocrystals-vivo.html Nanomaterials Thu, 14 Jan 2021 09:20:27 EST news529838424 The sudden deaths of some 330 elephants in northwestern Botswana earlier this year may have occurred because they drank water contaminated by toxic blue-green algae, the government announced Monday. /news/2020-09-elephants-botswana-died-toxic-algae.html Ecology Mon, 21 Sep 2020 09:56:22 EDT news519900973 Photothermal therapy (PTT) is a promising alternative method for cancer treatment due to advantages of non-invasiveness, precise temporal and spatial control, strong specificity and high tumor destruction efficiency. /news/2020-08-strategy-tumor-photothermal-therapy-real-time.html Bio & Medicine Thu, 06 Aug 2020 11:59:19 EDT news515933957 As humanity develops new types of plastics and chemicals, researchers are constantly trying to keep up with understanding how these contaminants affect the environment and wildlife. A new study gives a first look at the presence and potential effects of these pollutants in stranded dolphins and whales along the coast of the southeastern United States. /news/2020-08-tracking-humanity-latest-toxins-stranded.html Ecology Wed, 05 Aug 2020 03:13:15 EDT news515815990 A research team from the SEAaq group at the Universitat Autònoma de Barcelona conducted analyses to determine whether the microplastics contaminating the Mediterranean Sea can also be found inside the organism of the deep-sea shrimp (Aristeus antennatus), and what effects these could have on the animal's health and on human consumption. The study was conducted in three fishing zones off the coasts of Girona, Barcelona and Delta de l'Ebre in Tarragona, during the years 2017 and 2018. Some of these samples, such as the ones from Barcelona, were compared to others from more than 10 years ago, in order to establish the changes in microplastics concentrations within a ten-year period. /news/2020-07-microplastics-shrimp-harmless-animal-health.html Environment Tue, 21 Jul 2020 11:34:39 EDT news514550077 A protein derived from the saliva of the tick Amblyomma sculptum has been successfully used by researchers at the Butantan Institute in São Paulo, Brazil, to treat skin cancer (melanoma) in horses. The results of the study are described in the journal Scientific Reports. /news/2020-06-protein-derived-saliva-effective-treatment.html Veterinary medicine Mon, 29 Jun 2020 12:21:21 EDT news512652076