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Materials Science Mar 22, 2025

Researchers pioneer groundbreaking light-driven method to create key drug compounds

Researchers at Indiana University and Wuhan University in China have unveiled a groundbreaking chemical process that could streamline the development of pharmaceutical compounds, chemical building blocks that influence how ...

Biotechnology Mar 21, 2025

Computational drug discovery: Exploring natural products targeting SARS-CoV-2

The COVID-19 pandemic highlighted the urgent need for effective therapeutic agents against SARS-CoV-2. Although vaccines helped control the spread of the virus, the emergence of new variants continues to challenge global ...

Biochemistry Mar 11, 2025

Drug building blocks pave path to new sepsis treatments

The immune system can typically ramp up the body's defenses to clear out an invading threat without issue. Glitches can happen, however, with sepsis occurring when the mustered army of cells also attacks the body's own tissues ...

Cell & Microbiology Feb 27, 2025

Phoenix Fluor 555: Ultra-photostable fluorescent molecule reveals hidden dynamics of intracellular proteins

A research team at POSTECH (Pohang University of Science and Technology) has successfully developed a super-photostable organic dye after two years of dedicated research. Their study is published in the journal Nature Methods.

Biochemistry Feb 21, 2025

Synthesis method unlocks a pathway to valuable fluorinated drug compounds for new medicines

Researchers from the National University of Singapore (NUS) have pioneered a new catalytic transformation that converts epoxides into fluorinated oxetanes, a coveted but difficult-to-make class of drug molecules that escaped ...

Biochemistry Feb 20, 2025

Surprise discovery shows zinc-carrying proteins can activate acid reducing drugs without the presence of gastric acid

Acid reducing medicines from the group of proton pump inhibitors (PPIs) are best-selling drugs that prevent and alleviate stomach problems. PPIs are activated in the acid-producing cells of the stomach, where they block acid ...

Biochemistry Feb 4, 2025

Precise binding free energy calculations unlock new frontiers in drug design

Drug discovery is a costly and time-intensive process, with binding free energy calculations between the potential drug molecule and the target being crucial for reducing drug discovery costs, streamlining the process and ...

Biochemistry Jan 27, 2025

Team uses AI and quantum computing to target 'undruggable' cancer protein

Research co-led by University of Toronto researchers and Insilico Medicine has demonstrated the potential of quantum computing and artificial intelligence to transform the drug discovery pipeline.

Bio & Medicine Jan 24, 2025

Peptide-coated nanoparticles achieve 98% drug loading, improving cancer treatment

A team of scientists has developed a groundbreaking approach using specially designed peptides to improve drug formulations. This innovative method significantly enhances anti-tumor efficacy, as demonstrated in leukemia models. ...

Cell & Microbiology Jan 24, 2025

Using AI machine learning to map hidden molecular interactions in bacteria

A new study from Oregon Health & Science University has uncovered how small molecules within bacteria interact with proteins, revealing a network of molecular connections that could improve drug discovery and cancer research.

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