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Cell & Microbiology Jan 24, 2025

Using AI machine learning to map hidden molecular interactions in bacteria

A new study from Oregon Health & Science University has uncovered how small molecules within bacteria interact with proteins, revealing a network of molecular connections that could improve drug discovery and cancer research.

Molecular & Computational biology Jan 23, 2025

Toward video generative models of the molecular world

As the capabilities of generative AI models have grown, you've probably seen how they can transform simple text prompts into hyperrealistic images and even extended video clips.

Cell & Microbiology Jan 21, 2025

Structural insights reveal drug target in trypanosome parasites

A new study from the Kowalinski group at EMBL Grenoble characterized the structure of an important trypanosomal protein complex, potentially paving the way for novel drug discovery in the future. The research is published ...

Biochemistry Jan 13, 2025

Drug candidates target metabolic pathway in bacteria while sparing human cells

Antibiotics are a double-edged sword—they should be as toxic as possible to pathogenic bacteria while being harmless to the cells of the human body. An international research team led by the Helmholtz Institute for Pharmaceutical ...

Biochemistry Jan 9, 2025

Chemists unlock potential of ketone and ester molecules, paving way for greener and more efficient drug development

Scientists have long considered ketones (a fundamental chemical class) and esters (molecules formed when an acid reacts with an alcohol) to be locked treasure chests of possibilities. Ubiquitous as pharmaceutical intermediates, ...

Bio & Medicine Jan 7, 2025

Scientists develop nanobody inhibitors to target deadly Ebola virus

Ebola virus, one of the deadliest pathogens, has a fatality rate of about 50%, posing a serious threat to global health and safety. To address this challenge, researchers at the University of Minnesota and the Midwest Antiviral ...

Biochemistry Jan 6, 2025

How a single nitrogen atom could transform the future of drug discovery

Researchers at the University of Oklahoma have developed a breakthrough method of adding a single nitrogen atom to molecules, unlocking new possibilities in drug research and development. Now published in the journal Science, ...

Molecular & Computational biology Dec 23, 2024

Researchers develop tool to fast-track measurement of protein interactions for drug discovery

A team led by researchers at the University of Toronto has created a platform, called SIMPL2, that improves the study of protein-protein interactions by simplifying detection while improving measurement accuracy.

Bio & Medicine Dec 23, 2024

Ultrasound-activated nanoparticles deliver drugs to targeted brain regions

While ultrasound has been widely used for medical imaging, it also has a variety of therapeutic applications. The technology could potentially facilitate the release of medication in precise locations for disorders and conditions ...

Materials Science Dec 19, 2024

New synthesis technique cuts drug development time and cost

A team of chemists from Scripps Research and Rice University has unveiled a novel method to simplify the synthesis of piperidines, a key structural component in many pharmaceuticals. The study, published in Science, combines ...

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