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Biochemistry Feb 15, 2024

Superbug killer: New synthetic molecule highly effective against drug-resistant bacteria

A new antibiotic created by Harvard researchers overcomes antimicrobial resistance mechanisms that have rendered many modern drugs ineffective and are driving a global public health crisis.

Biochemistry Feb 14, 2024

Discovery of new plant protein fold may be seed for anti-cancer drugs

University of Michigan researchers are celebrating their discovery of a new plant biochemistry and its unusual ability to form cyclic peptides—molecules that hold promise in pharmaceuticals as they can bind to challenging ...

Molecular & Computational biology Feb 14, 2024

AI tool predicts function of unknown proteins

A new artificial intelligence (AI) tool that draws logical inferences about the function of unknown proteins promises to help scientists unravel the inner workings of the cell.

Space Exploration Feb 12, 2024

Astronauts from NASA's Expedition 71 to conduct research aboard space station

Studies of neurological organoids, plant growth, and shifts in body fluids are among the scientific investigations that NASA astronauts Matthew Dominick, Michael Barratt, Jeanette Epps, and Tracy C. Dyson will help support ...

Biotechnology Feb 8, 2024

New research with implications for drug discovery makes it possible to visualize the smallest protein clusters

Penn Engineers have pioneered a new way to visualize the smallest protein clusters, skirting the physical limitations of light-powered microscopes and opening new avenues for detecting the proteins implicated in diseases ...

Biochemistry Jan 30, 2024

New drug reveals a key mechanism to overcome resistance to protein degraders

Protein degraders, a novel approach in drug discovery, show promise in tackling diseases previously thought to be untreatable. Unlike traditional drugs that block specific protein functions, degraders alter the cell's natural ...

Analytical Chemistry Jan 19, 2024

AI-driven platform discovers PHD inhibitor for anemia treatment

A study published in the Journal of Medicinal Chemistry reports the discovery of a novel PHD inhibitor for the treatment of anemia.

Biochemistry Jan 16, 2024

Molecular 'super-glue' shows promise of cancer drug discovery platform

St. Jude Children's Research Hospital scientists have published their work on SJ3149, a compound with broad activity against many cancer types, particularly acute myeloid leukemia (AML). SJ3149 sticks to the cancer-related ...

Analytical Chemistry Jan 11, 2024

New catalytic technique creates key component of incontinence drug in less time

A research group at Nagoya University in Japan has developed a new catalyst that promises to revolutionize the asymmetric synthesis of pharmaceuticals called chiral macrocyclic dilithium(I) salt. It overcomes the lack of ...

Biochemistry Jan 11, 2024

Scientists tame chaotic protein fueling 75% of cancers

MYC is the shapeless protein responsible for making the majority of human cancer cases worse. UC Riverside researchers have found a way to rein it in, offering hope for a new era of treatments.

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