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Cell & Microbiology Feb 10, 2022

Researchers devise sex-cell precursors with staying power

Human primordial germ cells (PGCs) are the early precursors of the eggs (oocytes) and sperm that are necessary to keep humankind alive and reproducing. Medical researchers attempt to study their function and development using ...

Cell & Microbiology Feb 8, 2022

More monitoring and improved procedures needed in study of cell processes and research reproducibility

Culture environments of different cell types growing in culture vessels or Petri dishes vary significantly from each other and from conditions in the living body, potentially driving the "reproducibility crisis" in biomedical ...

Biotechnology Jan 31, 2022

A new method for mapping gene expression deep in the body could one day be used to track stem cells or cancer therapy

Even fans of black-and-white film can't deny that color brought new life to photography and motion pictures. And when it comes to learning what happens inside the body, there's no substitute for color. Were it possible, for ...

Cell & Microbiology Jan 28, 2022

Mutant stem cells defy rules of development

Imagine you're baking a cake, but you run out of salt. Even with the missing ingredient, the batter still looks like cake batter, so you stick it in the oven and cross your fingers, expecting to end up with something pretty ...

Cell & Microbiology Jan 27, 2022

Induced pluripotent bovine stem cells overcome decades-long challenges for cultivated meat

Stem cells have been used for years as therapeutics for human health, but new research shows they may offer the promise of making the global food supply more sustainable and reliable through the development of cultivated ...

Cell & Microbiology Jan 24, 2022

Fat's unexpected role in muscle stem cell fate

Scientists have shown for the first time that fat inside adult muscle stem cells regulates their fate.

Cell & Microbiology Jan 21, 2022

Increasingly efficient production of human pluripotent stem cells

Researchers at the University of Helsinki have developed a new, faster and more reliable technique for reverting human cells to the stem cell state. Pluripotent stem cells are a key tool in biomedicine for modeling various ...

Biotechnology Jan 6, 2022

Synthetic gene circuits that improve stem cell quality

Because iPS cells can be made into just about any cell type in the body, they have great promise for cell therapies. One major problem, however, is that not all reprogramming cells successfully become iPS cells, resulting ...

Cell & Microbiology Jan 3, 2022

Changing 'sponginess' of cell nuclei help them decide their future

Researchers from Tokyo Metropolitan University have discovered how the sponginess and stickiness of stem cell nuclei controls how they "differentiate" into specialized cells. They found that the nucleus starts solid-like ...

Cell & Microbiology Dec 21, 2021

Protein domain structures affect the quality of stem cells

The original iPS cells were reprogrammed by transducing four genes: OCT3/4, SOX2, KLF4, and c-MYC. Later experiments would show that c-MYC can be replaced with MYCL. Both are MYC proteins and thus oncogenes, but animal experiments ...

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