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Cell & Microbiology Jan 9, 2024

Researchers engineer skin bacteria that are able to secrete and produce molecules that treat acne

International research led by the Translational Synthetic Biology Laboratory of the Department of Medicine and Life Sciences (MELIS) at Pompeu Fabra University has succeeded in efficiently engineering Cutibacterium acnes, ...

Biotechnology Jan 8, 2024

Engineering tomatoes for high-yield saffron apocarotenoid production

Apocarotenoids, derived from the oxidative cleavage of carotenoids by carotenoid cleavage dioxygenases (CCDs), are crucial for biological functions in plants and animals, though their definition varies among scientific communities. ...

Biotechnology Jan 8, 2024

Researchers engineer in vivo delivery system for prime editing, partially restoring vision in mice

Prime editing, a versatile form of gene editing that can correct most known disease-causing genetic mutations, now has a new vehicle to deliver its machinery into cells in living animals.

Molecular & Computational biology Dec 21, 2023

Unlocking the genetic secrets of drought resilience in Persian walnuts

The walnut (Juglans regia L.), which was domesticated in ancient Persia, is a globally cultivated nut crop. With global water scarcity, walnut production is facing significant challenges due to abiotic stresses, especially ...

Bio & Medicine Dec 21, 2023

Researchers develop self-assembling, self-illuminating therapeutic proteins

When it comes to delivering drugs to the body, a major challenge is ensuring that they remain in the area they're treating and continuing to deliver their payload accurately. While major strides have been made in delivering ...

Biotechnology Dec 20, 2023

How researchers are 'CReATiNG' synthetic chromosomes faster and cheaper

A new technique invented by researchers at the USC Dornsife College of Letters, Arts and Science may revolutionize the field of synthetic biology. Known as CReATiNG (Cloning Reprogramming and Assembling Tiled Natural Genomic ...

Cell & Microbiology Dec 13, 2023

Research discovers that mice possess a natural gene therapy system

A previously mysterious small RNA molecule in mice is found to play a crucial role in gene expression, and may be the first identified member of a new class of regulatory RNAs.

Biotechnology Dec 11, 2023

Unlocking the secrets of synthetic biology: Host physiology over phylogeny in genetic circuit performance

Broad host range (BHR) synthetic biology aims to capitalize on a wide range of microbial phenotypes to expand biodesign applications not confined to traditional model organisms. Despite the ever-expanding genetic toolkit, ...

Bio & Medicine Dec 11, 2023

Genetically engineered cell therapies with mRNA lipid nanoparticles for transferrable platelets

Platelet transfusions are essential in managing bleeding and hemostatic dysfunction, and can be expanded to be used as cell therapy for a variety of diseases. The efforts to create such cell therapies require that researchers ...

Biochemistry Dec 6, 2023

Engineering customizable bio-adhesives for personalized medical repair

Traditional medical adhesives used in surgical applications often have limited bio-absorbability, high toxicity and a lack of customizability, leading to suboptimal surgical outcomes. Recent advances in synthetic biology ...

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