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Cell & Microbiology Dec 13, 2023

Research discovers that mice possess a natural gene therapy system

A previously mysterious small RNA molecule in mice is found to play a crucial role in gene expression, and may be the first identified member of a new class of regulatory RNAs.

Biotechnology Dec 11, 2023

Unlocking the secrets of synthetic biology: Host physiology over phylogeny in genetic circuit performance

Broad host range (BHR) synthetic biology aims to capitalize on a wide range of microbial phenotypes to expand biodesign applications not confined to traditional model organisms. Despite the ever-expanding genetic toolkit, ...

Bio & Medicine Dec 11, 2023

Genetically engineered cell therapies with mRNA lipid nanoparticles for transferrable platelets

Platelet transfusions are essential in managing bleeding and hemostatic dysfunction, and can be expanded to be used as cell therapy for a variety of diseases. The efforts to create such cell therapies require that researchers ...

Biochemistry Dec 6, 2023

Engineering customizable bio-adhesives for personalized medical repair

Traditional medical adhesives used in surgical applications often have limited bio-absorbability, high toxicity and a lack of customizability, leading to suboptimal surgical outcomes. Recent advances in synthetic biology ...

Cell & Microbiology Nov 28, 2023

Reprogramming tissue mechanically to promote wound healing

Researchers at PSI and ETH Zurich have taken connective tissue cells that have been mechanically reprogrammed to resemble stem cells and transplanted them into damaged skin. In their laboratory experiment, they were able ...

Bio & Medicine Nov 27, 2023

New platform solves key problems in targeted drug delivery

In recent years, cell and gene therapies have shown significant promise for treating cancer, cystic fibrosis, diabetes, heart disease, HIV/AIDS and other difficult-to-treat diseases. But the lack of effective ways to deliver ...

Bio & Medicine Nov 15, 2023

Engineering bacteria to biosynthesize intricate protein complexes

Protein cages found within microbes help its contents weather the harsh intracellular environment—an observation that has many bioengineering applications. Tokyo Tech researchers have recently developed an innovative bioengineering ...

Molecular & Computational biology Nov 14, 2023

Preventing pollen-mediated gene flow from transgenic camelina using engineered cleistogamy

Camelina sativa (L.) Crantz. is native to Europe and Central Asia, and cultivated as an oilseed crop in Europe, Asia, and North America. It is not only rich in nutrients, such as a high content of unsaturated fatty acids, ...

Bio & Medicine Nov 2, 2023

Re-engineered pseudoviruses for 3D mapping of infections open up new horizons in virus research

Pseudoviruses resemble impostors: Although harmless, they are designed in such a way that they can hardly be distinguished from their dangerous relatives. This makes them an invaluable tool in virus research. They can be ...

Bio & Medicine Oct 30, 2023

'Plug and play' nanoparticles could make it easier to tackle various biological targets

Engineers at the University of California San Diego have developed modular nanoparticles that can be easily customized to target different biological entities such as tumors, viruses or toxins. The surface of the nanoparticles ...

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