When targeting problem proteins involved in causing or spreading disease, a drug will often clog up a protein's active site so it can't function and wreak havoc. New strategies for dealing with these proteins can send these ...
G protein-coupled receptors (GPCRs) are the largest and most diverse group of cell surface proteins in humans. These receptors, which can be seen as "traffic directors," transmit signals from the outside to the inside of ...
In the latest stride toward combating neovascular age-related macular degeneration (nAMD), a team led by Professor Nathan Gianneschi from the International Institute for Nanotechnology at Northwestern University has unveiled ...
Scientists have breathed new life into the study of a protein with an outsized link to human cancers because of its dangerous mutations, using advanced research techniques to detect its hidden regions.
Despite its fundamental role in biology and extensive studies over half a century, many aspects of how DNA's building blocks are formed remain unclear. Now, an international team of scientists has revealed valuable details ...
Searching for new ways to block the growth of cancer cells is like looking for a needle in a haystack. Tumor cells rely on thousands of proteins to function, but only a few of those proteins can be precisely targeted by drugs ...
Biological cells contain in-built "housekeeping" mechanisms for taking care of damaged cellular structures. This includes the ubiquitin‒proteasome system (UPS), which selectively tags unwanted proteins with the ubiquitin ...
According to textbooks, proteins work by folding into stable 3D shapes that, like Lego blocks, precisely fit with other biomolecules.
Researchers at the University of Cologne's CECAD Cluster of Excellence for Aging Research and the CEPLAS Cluster of Excellence for Plant Sciences have found a promising synthetic plant biology approach for the development ...
A large team of international researchers have used techniques at ANSTO's Australian Synchrotron to understand how key proteins contribute to the virulence of the rabies virus, sometimes called the "zombie virus."
