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Search results for CRISPR-Cas9

Cell & Microbiology Mar 3, 2025

CRISPR-based method enhances detection of antibiotic resistance in wastewater

Antibiotic resistance is a global concern that threatens our ability to prevent and treat bacterial infections in humans and animals. To better monitor the emergence and spread of resistance, researchers at the Carl R. Woese ...

Biotechnology Feb 27, 2025

An ancient RNA-guided system could simplify delivery of gene editing therapies

A vast search of natural diversity has led scientists at MIT's McGovern Institute and the Broad Institute of MIT and Harvard to uncover ancient systems with the potential to expand the genome-editing toolbox. These systems, ...

Biotechnology Feb 17, 2025

NanoCas, a smaller version of CRISPR tested with a single AAV, delivers on-target results

Mammoth Biosciences researchers have developed NanoCas, an ultracompact CRISPR nuclease, demonstrating its ability to perform gene editing in non-liver tissues, including skeletal muscle, using a single adeno-associated virus ...

Biotechnology Feb 14, 2025

CRISPR system variant shows a novel DNA cleavage mechanism

Researchers have revealed new details about the CRISPR-Cas5-HNH/Cascade complex, a variant of the type I-E CRISPR-Cas system, providing insights into its DNA recognition and cleavage mechanisms.

Molecular & Computational biology Feb 13, 2025

Developmental biologists discover how a critical protein shapes gallbladder formation

The lab of Dr. Mark Magnuson, Louise B. McGavock Professor and professor of molecular physiology and biophysics at Vanderbilt University, has demonstrated that the formation of the gallbladder and bile duct system depends ...

Cell & Microbiology Feb 13, 2025

Gene editing approach sheds light on how mitochondria drive autophagy

Autophagy is the process by which cells digest and renew their internal structures, recycling damaged or malfunctioning proteins and organelles. By reusing these basic molecules, the cell gains the energy and resources needed ...

Biotechnology Feb 6, 2025

CRISPR technique helps reveal how bean genes could improve nitrogen fixation

Beans are a key food at the dietary level, boasting high nutritional value and constituting the most directly consumed legume. They also have a "superpower" in the field: they are able to fix nitrogen to the soil, so they ...

Cell & Microbiology Jan 30, 2025

New light-tuned chemical tools control processes in living cells

A research group at Umeå University has developed new advanced light-controlled tools that enable precise control of proteins in real time in living cells. This research opens doors to new methods for studying complex processes ...

Bio & Medicine Jan 28, 2025

Escaping the endosome: BEND lipids improve LNP mRNA delivery and gene editing

Every time a shuttle docks with the International Space Station (ISS), a delicate dance unfolds between the shuttle's docking system and its counterpart on the station. Thanks to international standards, these mechanisms ...

Cell & Microbiology Jan 14, 2025

Scientists reveal mechanism of key player in lysosome transport regulation

A research team led by Prof. Feng Wei at the Institute of Biophysics, Chinese Academy of Sciences, has made significant strides in understanding the BORC complex, a key player in lysosome transport and localization.

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