The tumor suppressor protein p53, known as "the guardian of the genome," protects the body's DNA from daily stress or long-term damage by triggering the cells to make repairs or to self-destruct. But mutations in the p53 ...
Scientists at St. Jude Children's Research Hospital have demonstrated how drug makers can avoid two key problems: toxicity and resistance. The researchers made slight changes to a small molecule to reduce its metabolism and ...
The virus that causes COVID-19, called SARS-CoV-2, uses its spike protein in order to stick to and infect our cells. The final step for the virus to enter our cells is for part of its spike protein to act like a twist tie, ...
Researchers at the Department of Chemical Engineering, Indian Institute of Technology, India, have investigated the effects of oxidative stress on the production of monoclonal antibodies (mAbs), and how antioxidants can alleviate ...
Researchers from Tokyo Metropolitan University and RIKEN CSRS have developed a new analytical platform based on liquid chromatography, mass spectrometry and software analysis that quantifies the structure of messenger RNA–based ...
When it comes to fighting off invaders, bacteria operate in a remarkably similar way to human cells, possessing the same core machinery required to switch immune pathways on and off, according to new University of Colorado ...
A group led by Prof. Horacio Cabral, in collaboration with a group led by Prof. Kazuhiro Kakimi, discovered a new way to improve cancer immunotherapy. Their findings are published in a paper, titled "An IL-12-Based Nanocytokine ...
The devil so often is in the details. For proteins that orchestrate the molecular business of life, there are devils and angels in their details, down to the proteins' constituent atoms. It's at that level of structural minutiae ...
Watching a puppet show can teach you something about how estrogen works in the body, according to Rice University scientists whose research could open the door to new strategies for regulating the hormone—which could ...
Scientists have created an AI system capable of generating artificial enzymes from scratch. In laboratory tests, some of these enzymes worked as well as those found in nature, even when their artificially generated amino ...
