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January 31, 2025

A delicate nanoflower that is downright deadly to bacteria

This elegant nanoflower adds antioxidant, antibacterial and antibiofilm properties when applied to electrospun nanofiber bandages. Credit: ACS Applied Bio Materials (2025). DOI: 10.1021/acsabm.4c00788
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This elegant nanoflower adds antioxidant, antibacterial and antibiofilm properties when applied to electrospun nanofiber bandages. Credit: ACS Applied Bio Materials (2025). DOI: 10.1021/acsabm.4c00788

A carnation-like nanostructure could someday be used in bandages to promote wound healing. Researchers in ACS Applied Bio Materials that laboratory tests of their nanoflower-coated dressings demonstrate antibiotic, anti-inflammatory and biocompatible properties.

They say these results show these and copper(II) phosphate sprouted nanoflower bandages are promising candidates for treating infections and inflammatory conditions.

Nanoflowers are tiny, self-assembling structures. But their large surface area provides plenty of space to attach drug molecules, making the flowers particularly suitable for delivering medications.

For their bandage blooms, Fatemeh Ahmadpoor, Pier Francesco Ferrari and colleagues chose copper(II) phosphate and tannic acid because of the antibiotic and anti-inflammatory properties of both reagents. After growing their flowers in a saline solution, the researchers attached the bioinspired structures onto strips of electrospun nanofiber fabric.

In tests, the nanoflower-coated bandages inactivated a broad spectrum of cultured bacteria (including E. coli, Pseudomonas aeruginosa and Staphylococcus aureus) and their antibiotic-resistant biofilms, scavenged , and didn't damage lab-grown human cells.

Ahmadpoor and Ferrari say these nanoflower-coated bandages represent a breakthrough advancement by providing a natural, cost-effective and highly efficient solution for combating infections and accelerating wound healing, with the potential to redefine treatment standards.

More information: Fatemeh Ahmadpoor et al, Self-Assembled Nanoflowers from Natural Building Blocks with Antioxidant, Antibacterial, and Antibiofilm Properties, ACS Applied Bio Materials (2025).

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Nanoflower-coated bandages, composed of copper(II) phosphate and tannic acid, exhibit antibiotic, anti-inflammatory, and biocompatible properties. These structures effectively inactivate a broad spectrum of bacteria, including antibiotic-resistant strains, and scavenge reactive oxygen species without harming human cells. This innovation offers a promising, cost-effective approach for infection treatment and wound healing.

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