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Steve Jobs, Bill Gates, and Mark Zuckerberg share more than just their status as tech icons—they are all part of the roughly 10% of the population that is left-handed.

And they're far from the only business luminaries who are members. Steve Forbes, Oprah Winfrey and Lou Gerstner (of IBM fame) are left-handed, as were John D. Rockefeller, Henry Ford and Ratan Tata.

Of course, this could be a mere coincidence—but perhaps not. The popular belief that left-handers think more creatively—and hence may enjoy an innovative edge in business—has been supported by cognitive neuroscience research, which shows that the left hand is controlled by the brain's right hemisphere, a region closely associated with creative thinking. However, conflicting findings and limited research evidence prevent broad conclusions about the correlation between creativity and handedness, let alone its potential implications for business leadership.

A recent by Long Chen and June Woo Park, two accounting professors at the Donald G. Costello College of Business, constitutes the first rigorous scholarly investigation into whether—and how—handedness plays a role in business innovation.

The paper was co-authored by Albert Tsang of Southern University of Science and Technology and Xiaofang Xu of Beijing Technology and Business University.

The researchers searched Google for photos and videos of S&P 500 CEOs engaged in activities like writing, throwing, drawing, and eating to determine their dominant hand, if it wasn't already disclosed in published sources.

"We looked at pictures of them on the golf course to see how they held their clubs," Park explains. "We also noted which wrist they wore their watch on; left-handed people often wear it on the right."

When in doubt, they followed up with calls or emails to the respective companies. All in all, they were able to identify the handedness of 1,008 CEOs across 472 companies: 91.4% were right-handed, 7.9% left-handed, and 0.7% mixed.

The researchers then looked at the numbers of patents and citations received by the firms from 1992 to 2015. They controlled for firm and industry characteristics, as well as other personal traits known to affect CEO innovativeness (such as age, education, risk preference shaped by experience, birth order, and founder status).

In addition, they performed several follow-up tests, including one focused on a narrow subset of firms that unexpectedly switched from a right-handed CEO to a left-handed one due to unforeseeable circumstances such as death or illness.

Every variation of the study produced essentially the same result: Firms led by left-handed CEOs demonstrate significantly higher innovative output. The differences were qualitative as well as quantitative. Patents under left-handed leadership were more likely to represent something new under the sun, rather than a spin-off from established technology.

The researchers hypothesized that the left-handers' creative orientation would impact the way they ran their firms, including hiring decisions. Indeed, they found that companies applied for more H-1B and STEM visas when left-handers were at the helm. This emphasis on talent acquisition was not only a key indicator of innovation commitment, but may have also contributed to the firms' creative advantage.

"We find that left-handed CEOs are more likely to hire immigrant inventors in STEM fields, and are also more likely to be inventors themselves," Chen says. "These findings strengthen our argument by highlighting specific ways in which left-handed CEOs may directly enhance firm innovation."

Still, piling up patents doesn't automatically produce outcomes that will make customers and shareholders happy. Ultimately, firm performance is what matters in evaluating business success. As additional analyses in the study suggest, firms led by left-handers had higher return on assets and stronger buy-and-hold returns than peers with a right-handed leader.

"They outperformed their counterparts," Park summarizes. "Investors are drawn to innovative firms, and left-handedness is one of the factors investors could use in their stock-picking."

Yet innovative success is complex and multifaceted. Left-handedness is only one potentially meaningful trait among many—a lot more are yet to be explored.

"Our results are based on a large sample. But investors should not assume a CEO that is not left-handed lacks innovative potential," Chen says.

For their ongoing and future research projects, Chen and Park are looking beyond left-handedness to explore other deeply personal CEO traits that may have business implications.

"We find it fascinating to draw on insights from disciplines outside accounting and finance," Chen says. "CEO decisions may be shaped by factors like family experiences, genetics, academic background, career paths, and more—really, the full range of experiences that makes them who they are. Understanding that can help market participants better interpret and predict CEOs' decision-making."