Credit: University of Nottingham

Scientists have discovered how a small protein in plants that acts like a molecular form of Velcro helps stick to other target proteins, creating new connections that enable plants to respond better to environmental stresses like drought, salt and pathogens.

Researchers from the University of Nottingham's School of Biosciences co-led the study in collaboration with the Universities of Durham, Liverpool and Cambridge. In a world first, the UK team has analyzed the entire molecular machinery that adds and takes away the SUMO Velcro strip. The results have been published in .

The team were able to detect where all 32 parts of the SUMO machinery are located by tagging each with a fluorescent tag, then studying which changed after exposure to .

This new study shows that different parts of the SUMO machinery are regulated by distinct environmental stresses. This new knowledge will help researchers to design more resilient crops for future climate conditions.

"Understanding how rapidly respond to stress using SUMO will be of great importance to provide novel targets for improving crop resilience in the face of climate change," says first author Jason Banda.

More information: Jason Banda et al, Elucidating tissue and subcellular specificity of the entire SUMO network reveals how stress responses are fine-tuned in a eukaryote, Science Advances (2025).

Journal information: Science Advances