麻豆淫院

Researchers at University of Tsukuba have identified genes and signaling pathways that trigger the death of individual insects under stress. The work is in the journal Proceedings of the National Academy of Sciences.

Organisms survive while enduring various stresses such as temperature, ultraviolet radiation, and interspecies interactions. Within tolerable limits, they can survive by exhibiting resistance. Nevertheless, when they are subjected to excessive stress beyond their capacity (lethal stress), individuals die. The mechanisms that control such stress-dependent individual death have remained unclear.

The research team conducted experiments using the fruit fly Drosophila melanogaster and identified Phaedra1 (Phae1) as a lethal stress-responsive gene that activates a protein essential for cell death in neurons and consequently induces individual death.

Phae1 activates a protein required for cell death in neurons, resulting in the induction of individual death. Researchers also determined that Phae1 expression is regulated by the transcription factor Zeste. Moreover, when exploring compounds that affect Phae1 expression, they found that rapamycin, an inhibitor of the signaling factor mTOR, suppresses Phae1 expression.

Specifically, neuronal-specific reduction of mTor function suppressed the expression of zeste and Phae1 and increased the survival rates after exposure to lethal stress. These findings suggest that the mTOR-Zeste-Phae1 pathway controls stress-induced individual death in D. melanogaster.