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Cell & Microbiology Aug 4, 2023

Researchers reveal role of protein oxidative folding in stem cell aging

It has been widely acknowledged for a long time that mitochondrion is the main source of reactive oxygen species (ROS). The role of the endoplasmic reticulum (ER)-generated ROS has been less extensively studied. It has been ...

Cell & Microbiology Jul 26, 2023

Generation of a human haploid neural stem cell line for genome-wide genetic screening

Haploid embryonic stem cells (haESCs) have been established in many species. Differentiated haploid cell line types in mammals are lacking due to spontaneous diploidization during differentiation that compromises lineage-specific ...

Cell & Microbiology Jul 26, 2023

Commitment of human mesenchymal stromal cells to skeletal lineages is independent of their morphogenetic capacity: Study

Mesenchymal stromal cells (MSCs) are multipotent cell populations obtained from fetal and adult tissues. They share some characteristics with limb bud mesodermal cells such as differentiation potential into osteogenic, chondrogenic, ...

Cell & Microbiology Jul 26, 2023

Zinc enhances cell adhesion, migration, self-renewal potential of human umbilical cord-derived mesenchymal stem cells

Zinc (Zn) is the second most abundant trace element after Fe, present in the human body. It is frequently reported in association with cell growth and proliferation, and its deficiency is considered to be a major disease ...

Cell & Microbiology Jul 24, 2023

Successful generation of functional parathyroid glands from mouse embryonic stem cells

Regenerative medicine has opened up exciting possibilities in the world of medicine. Now, researchers in Japan are searching for ways to recreate and rebuild body tissues and organs, which may be an alternative cure for diseases.

Cell & Microbiology Jul 17, 2023

A key function for tight junctions in embryo models

As a human embryo grows, a set of molecules directs cells as they multiply and take on specific identities and spatial positions within the embryo. In one crucial step known as gastrulation, these signaling molecules guide ...

Cell & Microbiology Jul 3, 2023

Transplantation of genome-edited iPS cells delivers therapeutic molecules in vivo

Induced pluripotent stem (iPS) cells have a great impact on biology and medicine, and they are expected to improve regenerative medicine. Since 2014, when a sheet of retinal pigment epithelial cells derived from iPS cells ...

Cell & Microbiology Jun 28, 2023

New stem cell research takes aim at origins of human cancers

How do cells become cancerous, multiply uncontrollably, and form into tumors? And what role do aberrant embryonic stem cells play? These are big questions explored by medical researchers since the embryonic theory of cancer ...

Molecular & Computational biology Jun 27, 2023

Scientists use stem cells to create models of human embryos and study our earliest days

Scientists have created embryo models to help study the mysteries of early human development, the medical problems that happen before birth and why many pregnancies fail.

Plants & Animals Jun 20, 2023

Researchers use stem cell zoo to compare six mammalian species and their developmental time

In humans, pregnancy lasts around nine months. In mice, only 20 days, and in rhinoceroses, as long as 17 months. Although many mammalian species go through the same stages during embryo development, the speed of development ...

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