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Biochemistry Aug 30, 2024

Study combines data and molecular simulations to accelerate drug discovery

Researchers from the University of Cincinnati College of Medicine and Cincinnati Children's Hospital have found a new method to increase both speed and success rates in drug discovery.

Biochemistry Aug 27, 2024

New technique for studying cell receptors could have sweeping implications for drug development

One in every three FDA-approved drugs targets a single superfamily of receptors dotting the surfaces of human cells. From beta blockers to antihistamines, these essential, life-saving medications trigger winding biochemical ...

Molecular & Computational biology Aug 23, 2024

New approach for profiling complex dynamics at the single-molecule level

A team of researchers led by Professor Sebastian Deindl at Uppsala University has developed a pioneering method that vastly improves the ability to observe and analyze complex biological processes at the single-molecule level. ...

Molecular & Computational biology Aug 22, 2024

A small molecular glue that increases P53 level and suppresses tumor growth in vivo

Molecular glues are typically small chemical molecules that act on the interface between the target protein and the degradation machinery to trigger ternary complex formation. Identification of molecular glues is challenging, ...

Analytical Chemistry Aug 18, 2024

Peering into the mind of artificial intelligence to make better antibiotics

Artificial intelligence (AI) has exploded in popularity. It powers models that help us drive vehicles, proofread emails and even design new molecules for medications. But just like a human, it's hard to read AI's mind.

Plants & Animals Aug 15, 2024

Cactus dreams: Revealing the secrets of mescaline making

Mescaline, a natural hallucinogen known since ancient times, was not only a favorite of artists and bohemians but also a mainstay of brain research throughout the first half of the 20th century, until it was eclipsed in the ...

Analytical Chemistry Aug 8, 2024

New ligand-guided technique enhances drug development

Achieving a level of precision to create complex medicines and materials with extreme accuracy is a longstanding goal of scientists and pharmaceutical companies. If achieved, that precision could lead to the development of ...

Plants & Animals Aug 8, 2024

DNA Topoisomerase insights hold potential for drug discovery and plant protection

Insights into the function of DNA Topoisomerase VI (Topo VI) may provide a springboard for drug discovery and crop protection.

Biotechnology Aug 8, 2024

AI predicts 3D structures of receptors for drug development

Artificial intelligence (AI) can help identify molecules that could serve as new drugs for mental health disorders. AI can be used to predict the three-dimensional structures of important receptors and thereby speed up the ...

Biotechnology Aug 2, 2024

BNP-Track algorithm offers a clearer picture of biomolecules in motion

It's about to get easier to catch and analyze a high-quality image of fast-moving molecules. Assistant Professor Ioannis Sgouralis, Department of Mathematics, and colleagues have developed an algorithm that adds a new level ...

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