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Cell & Microbiology Aug 1, 2024

Researchers elucidate mechanisms behind protein selectivity in adenosine receptor

In a new study, a multinational research team led by Dr. Adnan Sljoka (RIKEN) and Prof. Akio Kitao (Tokyo Tech), in collaboration with Prof. Scott Prosser (University of Toronto), has carried out experimental and computational ...

Biotechnology Aug 1, 2024

Researchers find unknown effects of existing drugs by mapping protein interactions

Fewer side effects, improved chances of healing: The goal of precision medicine is to provide patients with the most individualized treatment possible. This requires a precise understanding of what is happening at the cellular ...

Biotechnology Jul 31, 2024

High-performance computing and quantum chemistry advances drug discovery

Led by University of Melbourne theoretician and HPC expert Associate Professor Giuseppe Barca, a research team has achieved the first quantum simulation of biological systems at a scale necessary to accurately model drug ...

Molecular & Computational biology Jul 30, 2024

New derivative from long pepper shows promise against antibiotic resistance

Antibiotic resistant bacterial pathogens are on the rise, while fewer antibiotics are being developed. Prof. Ariel Kushmaro and his local and international colleagues tackled the need by focusing on the long pepper. Known ...

Biochemistry Jul 23, 2024

Research team develops new antimalarial agent for combating drug-resistant parasites

Malaria remains a serious health issue globally, especially in Africa. The disease is caused by protozoan parasites in the Plasmodium genus. In 2021, there were 247 million cases of malaria and 619,000 deaths reported worldwide.

Biochemistry Jul 22, 2024

Discovery of daphnane diterpenoids in Daphne pedunculata could lead to new HIV drugs

A research group led by Professor Wei Li of the Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Toho University, in collaboration with Shenyang Pharmaceutical University in China and Duke University Medical ...

Analytical Chemistry Jul 18, 2024

New AI approach accelerates targeted materials discovery and sets the stage for self-driving experiments

Scientists have developed an AI-based method that helps gather data more efficiently in the search for new materials, allowing researchers to navigate complex design challenges with greater precision and speed.

Biochemistry Jul 18, 2024

De-risking drug discovery with predictive AI

Developing a new drug can take years of research and cost millions of dollars. Still, more than 90% of drug candidates fail in clinical trials, with even more that never make it to the clinical stage. Many drugs fail because ...

Analytical Chemistry Jul 17, 2024

Chemists develop modular approach for creating important class of pharmaceutical compounds

Chemists at the National University of Singapore (NUS) have developed a modular approach to create 1,2-arylheteroaryl ethanes, a class of compounds important for drug discovery and pharmaceutical development, using fundamental ...

Biochemistry Jul 12, 2024

A comprehensive derivative synthesis method for development of new antimicrobial drugs

Efforts to combat the increasing threat of drug-resistant bacteria are being assisted by a new approach for streamlining the search for antimicrobial drug candidates, pioneered by researchers at Hokkaido University, led by ...

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