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Analytical Chemistry Jun 7, 2024

Peptidomimetics open new opportunities in drug discovery

A relatively simple peptide modification could unlock a whole class of targets for drug discovery, new research shows.

Cell & Microbiology Jun 5, 2024

Antibiotic discovery effort uses AI to uncover potential new antibiotics in the global microbiome

Almost a century ago, the discovery of antibiotics like penicillin revolutionized medicine by harnessing the natural bacteria-killing abilities of microbes. Now, a new study co-led by researchers at the Perelman School of ...

Analytical Chemistry May 30, 2024

Scientists develop most sensitive method yet for observing single molecules

Scientists at the University of Wisconsin–Madison have developed the most sensitive method yet for detecting and profiling a single molecule—unlocking a new tool that holds potential for better understanding how the building ...

Biochemistry May 23, 2024

Unlocking complex sulfur molecules: A novel approach for synthesis of functionalized benzenethiol equivalents

Organosulfur compounds, organic compounds containing sulfur, are vital in biological processes and research fields like pharmaceuticals, biomedical imaging, agriculture, and electronics. Compounds like phenothiazine, thianthrene ...

Molecular & Computational biology May 16, 2024

How can understanding misfolded proteins help improve disease treatments?

Proteins are like tiny machines in our bodies, helping with almost everything we do, including breaking down food, carrying messages between cells, and building and repairing tissues, like muscles and skin.

Biotechnology May 16, 2024

Protein prediction technology yields accurate results to efficiently find the best drug candidate for many conditions

Artificial intelligence (AI) has numerous applications in health care, from analyzing medical imaging to optimizing the execution of clinical trials, and even facilitating drug discovery.

Biochemistry May 8, 2024

A multi-stream network for retrosynthesis prediction

Retrosynthesis aims to predict a set of reactants for producing given molecules, which plays a significant part in the biochemistry field, such as molecular pathway design and drug discovery. Most existing methods only benefit ...

Cell & Microbiology May 6, 2024

Researchers develop new AI tool for fast and precise tissue analysis to support drug discovery and diagnostics

A team of scientists from A*STAR's Genome Institute of Singapore (GIS) and Bioinformatics Institute (BII) has developed a new AI software tool called "BANKSY" that automatically recognizes the cell types present in a tissue, ...

Biochemistry May 6, 2024

Simulated chemistry: New AI platform designs tomorrow's cancer drugs

Scientists at UC San Diego have developed a machine learning algorithm to simulate the time-consuming chemistry involved in the earliest phases of drug discovery, which could significantly streamline the process and open ...

Biochemistry Apr 25, 2024

A shortcut for drug discovery: Novel method predicts on a large scale how small molecules interact with proteins

For most human proteins, there are no small molecules known to bind them chemically (so-called "ligands"). Ligands frequently represent important starting points for drug development but this knowledge gap critically hampers ...

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