See also stories tagged with Drug discovery
A new computer process developed by chemists at ETH Zurich makes it possible to generate active pharmaceutical ingredients quickly and easily based on a protein's three-dimensional surface. The new process, detailed in Nature ...
Inspired by what human liver enzymes can do, Scripps Research chemists have developed a new set of copper-catalyzed organic synthesis reactions for building and modifying pharmaceuticals and other molecules. The new reactions ...
Researchers have discovered ways to convert inhibitor-style targeted cancer drugs into small molecules known as degraders, which help destroy cancer-promoting proteins in cells.
Scientists have successfully used a new imaging technique to determine the structure and interactions of a protein complex that plays a significant part in the initiation and progression of cancer. They showed that it was ...
A new automated workflow developed by scientists at Lawrence Berkeley National Laboratory (Berkeley Lab) has the potential to allow researchers to analyze the products of their reaction experiments in real time, a key capability ...
Researchers at The University of Manchester have developed a new catalyst which has been shown to have a wide variety of uses and the potential to streamline optimization processes in industry and support new scientific discoveries.
The active ingredient in many drugs is what's known as a small molecule: bigger than water, much smaller than an antibody and mainly made of carbon. It's tough, however, to make these molecules if they require a quaternary ...
The Janus kinase 2 (JAK2) protein mediates signaling from several cytokine receptors in the regulation of hematopoiesis and immune responses. Somatic mutations in human JAK2 lead to constitutive activation and cytokine-independent ...
Scientists from the University of Oulu (Finland) and Texas A&M University (U.S.), have developed a new method to study how proteins interact with small ligand molecules, paving the way, for example, for faster and more efficient ...
Droplet microfluidics has revolutionized single-cell analysis, crucial for genomics, drug discovery, and diagnostics, by partitioning samples into nanoliter droplets for detailed cellular analysis. Yet, its broader adoption ...
