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Biochemistry Oct 31, 2023

A powerful tool for rapid natural product gem-dimethylation modification in drug design

Tylophorine has diverse biological activities; however, the stability, solubility, and central nervous system toxicity have severely limited use of tylophorine. The gem-dimethyl group is an organic chemistry functional group ...

Quantum Âé¶¹ÒùÔºics Oct 26, 2023

New quantum computing architecture achieves electron charge qubit with 0.1 millisecond coherence time

Coherence stands as a pillar of effective communication, whether it is in writing, speaking or information processing. This principle extends to quantum bits, or qubits, the building blocks of quantum computing. A quantum ...

Biochemistry Oct 25, 2023

New tool developed to efficiently predict relative ligand binding affinity in drug discovery

Lead optimization in drug discovery is a challenging process that heavily relies on hypotheses and the experience of medicinal chemists. This often leads to uncertain outcomes and inefficiency. Furthermore, the process is ...

Quantum Âé¶¹ÒùÔºics Oct 9, 2023

Speeding up creation of quantum entanglement

A team of researchers has found a way to speed up the creation of quantum entanglement, a mystifying property of quantum mechanics that Albert Einstein once described as "spooky action at a distance."

Biochemistry Oct 5, 2023

Precise genome engineering and protein activity profiling uncover new cancer drug targets

Searching for new ways to block the growth of cancer cells is like looking for a needle in a haystack. Tumor cells rely on thousands of proteins to function, but only a few of those proteins can be precisely targeted by drugs ...

Biochemistry Sep 29, 2023

Machine learning helps predict drugs' favorite subcellular haunts

Most drugs are small molecules that bind firmly to a specific target—some molecule in human cells that is involved in a disease—in order to work. For example, a cancer drug's target might be a molecule that is abundant ...

Biochemistry Sep 25, 2023

Research team develops new way to target cancer cells

Researchers from the University of Arizona Cancer Center have identified a new method of activating specific molecules to target cancer cells while leaving healthy cells unharmed.

Analytical Chemistry Sep 22, 2023

Machine-learning-boosted drug discovery with 10-fold time reduction

Boosting virtual screening with machine learning allowed for a 10-fold time reduction in the processing of 1.56 billion drug-like molecules. Researchers from the University of Eastern Finland teamed up with industry and supercomputers ...

Biochemistry Sep 13, 2023

Natural compound found in plants inhibits deadly fungi

A new study finds that a natural compound found in many plants inhibits the growth of drug-resistant Candida fungi—including its most virulent species, Candida auris, an emerging global health threat. The journal ACS Infectious ...

Biochemistry Aug 31, 2023

Discovery opens possibility of new ion channel-targeting drugs

Ion channels are attractive drug targets due to their importance in health and disease, but finding ways to target a specific ion channel selectively is a major challenge. Now, researchers at Weill Cornell Medicine and RMIT ...

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