Genetic editing holds promise to treat incurable diseases, but the most popular method—CRISPR—sometimes does more harm than good. A new study from University of California San Diego and Yale University researchers highlights ...
Small but powerful: Ubiquitin controls the lifespan and distribution of proteins in the cell, but it can also determine their shape, function, or interactions with other cellular components. Ubiquitin ligases are key to this ...
A genome-editing technique known as prime editing holds potential for treating many diseases by transforming faulty genes into functional ones. However, the process carries a small chance of inserting errors that could be ...
Scientists at Feinberg are reshaping scientific understanding of the cell's tiniest components—structures once thought to be static, now revealed to be dynamic engines of cellular life. As they probe the inner workings ...
To solve a problem, we have to see it clearly. Whether it's an infection by a novel virus or memory-stealing plaques forming in the brains of Alzheimer's patients, visualizing disease processes in the body is the first step ...
Inside cells there are tiny particles, known as extracellular vesicles, that store and move molecules. Our cells naturally package beneficial proteins and healing compounds into these tiny bubbles, dispatching them to where ...
A pharmaceutical scientist at the National University of Singapore (NUS) has developed a method that can measure the kinetic efficiency of an enzyme against more than 200,000 potential peptide substrates in a single experiment.
Alexander Fleming's accidental discovery of penicillin in 1928 changed the world: Once-common bacterial infections, sometimes deadly, were treatable, and a slew of antibiotics followed. But bacteria have proven a wily adversary, ...
A novel strategy developed at Rice University allows scientists to zoom in on tiny segments of proteins inside living cells, revealing localized environmental changes that could indicate the earliest stages of diseases such ...
Neurodegenerative diseases like Alzheimer's, Parkinson's, and Huntington's disease are characterized by the progressive loss of neurons. The resulting debilitating symptoms, such as loss of memory and cognition, and motor ...
