A screening technique commonly used in drug discovery can yield important details about the actions of molecular 'glues' in protein interactions.
We rely on temporary protein-protein bonds for essential processes including enzymatic reactions, antibody binding, and response to medication. Being able to accurately characterize these bonds is important for testing the ...
Particles known as extracellular vesicles play a vital role in communication between cells and in many cell functions. Released by cells into their environment, these "membrane particles" consist of a cellular membrane carrying ...
Assemblies of tiny molecular proteins span the membranes that encapsulate our cells, directing cellular activities and regulating the transport of materials and information in and out.
Proteins tend to fold wrongly and become defective when exposed to stressors such as heat, oxidation, and pH changes. Accumulation of abnormal proteins contributes to neurodegenerative diseases like Alzheimer's.
Most researchers today understand biology through the principles of biochemistry. Cells communicate and activate processes via chemical signals, and traditional medicine has long focused on how to treat disease by modifying ...
Researchers at the University of Toronto have developed an artificial intelligence system that can create proteins not found in nature using generative diffusion, the same technology behind popular image-creation platforms ...
Scientists have developed new technology which has made it possible to isolate and study how a single protein—10,000 times thinner than a human hair—behaves and changes over time.
A team of researchers from the University of California, Irvine, have revealed the first crystal structures of the receptor-binding domain of botulinum neurotoxin E (BoNT/E) in complex with its human neuronal receptors, synaptic ...
Scripps Research scientists have developed a new strategy for identifying small molecules that can change the function of proteins, offering a promising path for discovering targeted drugs. In collaboration with scientists ...
