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Search results for CRISPR-Cas9

Biotechnology Oct 28, 2024

Researchers discover underlying mechanisms that make CRISPR an effective gene editing tool

CRISPR/Cas9 is a gene editing tool that has revolutionized biomedical research and led to the first FDA-approved CRISPR-based gene therapy. However, until now, the precise mechanism of exactly how this tool works and avoids ...

Cell & Microbiology Oct 14, 2024

Brazilian study identifies potential targets for treatment of visceral leishmaniasis

Researchers at the Federal University of São Carlos (UFSCar), the State University of Campinas (UNICAMP) and the University of São Paulo (USP) in Brazil have characterized for the first time a class of proteins present ...

Biotechnology Oct 2, 2024

Filament structure found to activate and regulate CRISPR-Cas 'protein scissors'

CRISPR-Cas systems help to protect bacteria from viruses. Several different types of CRISPR-Cas defense systems are found in bacteria, which differ in their composition and functions. Among them, the most studied proteins ...

Biotechnology Oct 1, 2024

Structure of a eukaryotic CRISPR-Cas homolog, Fanzor2, shows promise for gene editing

Scientists at St. Jude Children's Research Hospital have revealed how Fanzor2's divergence from bacterial ancestors may make it a useful tool for future genomic engineering endeavors.

Cell & Microbiology Sep 27, 2024

How a protein keeps gene clusters quiet in the cell nucleolus

In a discovery that sheds light on the complex mechanisms of gene regulation, scientists at EPFL have uncovered a critical role for the protein ZNF274 in keeping certain gene clusters turned off by anchoring them to the cell ...

Plants & Animals Sep 26, 2024

Scientists uncover a critical component that helps killifish regenerate their fins

Spontaneous injuries like the loss of a limb or damage to the spinal cord are impossible for humans to repair. Yet, some animals have an extraordinary capacity to regenerate after injury, a response that requires a precise ...

Biotechnology Sep 25, 2024

CRISPR-Cas13: A new frontier in RNA-editing with therapeutic potential

In recent years, the scientific community has made significant strides in the field of gene editing, particularly through the development of the CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) systems.

Biotechnology Sep 24, 2024

Increasing protein in staple crops could help alleviate global protein shortage

A Mississippi State biologist's research in improving global nutrition and sustainability is featured this week in New Phytologist.

Biotechnology Sep 23, 2024

Compact 'gene scissors' enable effective genome editing, may offer future treatment of high cholesterol gene defect

CRISPR-Cas is used broadly in research and medicine to edit, insert, delete or regulate genes in organisms. TnpB is an ancestor of this well-known "gene scissors" but is much smaller and thus easier to transport into cells.

Cell & Microbiology Sep 13, 2024

CRISPR/Cas9 modifies Euglena to create potential biofuel source

News about biofuels sometimes mentions used cooking oil as a feedstock, but if these substances contain animal fat, they can solidify in colder temperatures. This happens because, chemically, the fatty acids of these and ...

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