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Scientists reveal neuronal calcium oscillations involved in tissue communication

Scientists reveal neuronal calcium oscillations involved in tissue communication
Model of chronic mitochondrial stress leads to tmbim-2-dependent spatiotemporal Ca2+ waves to coordinate neuronal-to-intestinal UPRmt activation and aging. Credit: IGDB

Mitochondria play a crucial role in maintaining energy balance and cellular health. Recent studies have shown that chronic stress in neuronal mitochondria can have far-reaching effects, not only damaging the neurons themselves but also influencing other tissues and systemic metabolic functions.

A new study led by Dr. Tian Ye's research team at the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences (CAS) reveals that chronic mitochondrial stress in neurons promotes serotonin release via TMBIM-2-dependent calcium (Ca虏鈦) oscillations, which in turn activates the mitochondrial unfolded protein response (UPRmt) in the intestine. The findings are in the Journal of Cell Biology.

The researchers found that TMBIM-2 works in coordination with the plasma membrane calcium pump MCA-3 (a PMCA homolog) to regulate synaptic Ca虏鈦 balance, sustaining persistent calcium signaling oscillations at neuronal synaptic sites.

Further investigation showed that TMBIM-2 expression declines with age. In Caenorhabditis elegans, overexpression of TMBIM-2 significantly improved and extended lifespan in aged worms.

Notably, TMBIM-2 is highly conserved in humans and mice, and its expression similarly decreases with age in neural tissues, underscoring its broad biological significance in aging regulation.

In summary, this study highlights the critical role of neuronal calcium oscillations in cross-tissue signaling and lifespan regulation, providing new theoretical insights and potential therapeutic targets for aging intervention and metabolic health.

More information: Jiasheng Li et al, TMBIM-2 orchestrates systemic mitochondrial stress response via facilitating Ca2+ oscillations, Journal of Cell Biology (2025).

Journal information: Journal of Cell Biology

Citation: Scientists reveal neuronal calcium oscillations involved in tissue communication (2025, March 25) retrieved 21 August 2025 from /news/2025-03-scientists-reveal-neuronal-calcium-oscillations.html
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