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Could AI framework be the key to how collective cell intelligence works?

Artificial intelligence theory could be the key to how collective cell intelligence works
Researchers from The University of Tokyo have found that single cells in collective chemotaxis act like agents in distributed reinforcement learning, utilizing the environment as an "external memory" and exhibiting highly intelligent behavior. Credit: Institute of Industrial Science, The University of Tokyo

It has long been understood that groups of cells can perform complex tasks, such as navigating mazes or strategically colonizing new habitats, even though individual biological cells have only limited ability to respond to signals like chemical compounds in their immediate environment.

Now, scientists from Japan have developed a that may explain how surprisingly intelligent behavior arises in nature from such groups.

A research team from the Institute of Industrial Science, The University of Tokyo, found that the key is how the cells use their environment to incrementally process information and make decisions in a distributed manner. The research is in the journal PRX Life.

"We can describe these phenomena in detail using well-known physical models," says Masaki Kato, the first author of the study. "But understanding the computational principles at play is another matter."

To do this, the research team used the paradigm of applied in artificial intelligence. Reinforcement learning, unlike supervised and unsupervised machine learning, is ideal in this case because it is based on interaction with the environment.

Instead of operating to a set of pre-defined instructions, an individual agent simply probes the environment multiple times and sees what happens. It then adjusts its internal policy to maximize its reward over the long term.

The team considered a population of cells that cooperatively aim to move toward sparsely distributed targets (such as food) by modulating chemical signals that indicate a target is nearby.

The whole cell population acts as an agent that uses reinforcement learning to gradually determine the optimal navigation strategy without needing the guidance of a single leader.

Tetsuya J. Kobayashi, the study's senior researcher, says that this theory is the key to understanding how this type of distributed information processing works.

"In a certain sense, the environment plays the role of a working memory for consequences; it remembers and reflects the agent's past actions and exploration in the form of changed states."

Through simulations, the researchers demonstrated that even agents with limited intelligence can perform as a group, such as finding their way through a maze, through decentralized information processing and sharing (that is, without a leader).

They compared these agent populations with a single, more intelligent agent with a and found that the simple organisms performed more robustly than the single agent.

This work shows that decentralized swarms or teams of simple agents can coordinate to efficiently process information, a principle that could be used to address problems in various fields including medicine, , and robotics going forward.

More information: Masaki Kato et al, Optimality Theory of Stigmergic Collective Information Processing by Chemotactic Cells, PRX Life (2025).

Journal information: PRX Life

Provided by University of Tokyo

Citation: Could AI framework be the key to how collective cell intelligence works? (2025, October 16) retrieved 16 October 2025 from /news/2025-10-ai-framework-key-cell-intelligence.html
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