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Analytical Chemistry Jun 2, 2025

Enhancing molecular machine learning with quantum-chemical insight

Molecular machine learning (ML) underpins critical workflows in drug discovery, material science, and catalyst optimization by rapidly predicting molecular interactions and properties. For instance, in drug discovery, ML ...

Polymers May 30, 2025

Custom-designed polymers open new path to electrochemical separations for sustainable drug manufacturing

Enantiomers, or molecule pairs that are mirror images of each other, make up more than half of FDA-approved drugs in use today, including those used in treatments for cancer, neurologic diseases and arthritis. Separating ...

Biochemistry May 29, 2025

Harnessing the power of 'click chemistry' to make biomolecular labeling safe for live cells

One of the longstanding challenges in chemical biology has been finding ways to directly observe biological processes at work inside living cells without disturbing the action. In order to unlock new therapies and better ...

Optics & Photonics May 29, 2025

Quanta image sensors brings bioluminescent signals into sharper focus

Researchers at Helmholtz Munich and the Technical University of Munich have developed a new microscope that significantly improves how bioluminescent signals in living cells can be observed.

Cell & Microbiology May 29, 2025

Could 'pausing' cell death be the final frontier in medicine on Earth and beyond?

The process of necrosis, a form of cell death, may represent one of the most promising ways to change the course of human aging, disease and even space travel, according to a new study by researchers at UCL, drug discovery ...

Cell & Microbiology May 28, 2025

3D structure of key membrane repair proteins revealed by cryo-electron microscopy

Researchers from the Göttingen Cluster of Excellence Multiscale Bioimaging (MBExC) have uncovered the 3D structure of the membrane proteins myoferlin and dysferlin using high-resolution cryo-electron microscopy.

Molecular & Computational biology May 28, 2025

In nature's math, freedoms are fundamental

Numbers have a funny way about them. Young math students are taught various strategies to make problem-solving easier. Comparing fractions? Find a common denominator or convert to decimals. The strategies get more complex ...

Cell & Microbiology May 28, 2025

Combinatorial screening uncovers molecules that enhance antibiotics against resistant bacteria

Researchers have created a pipeline for discovering unique combinations of molecules that increase the effectiveness of antibiotics against drug-resistant bacteria. The team, led by scientists at the Broad Institute and the ...

Cell & Microbiology May 28, 2025

Mirror-image molecules deliver one-two punch to superbugs to fight infections

Since the discovery of penicillin nearly a century ago, antimicrobial resistance (AMR) has become a stealthy, pervasive enemy in the fight against bacterial infections. AMR claims an estimated 1.27 million lives a year and ...

Biochemistry May 22, 2025

One-pot protein screening accelerates bioscience and drug discovery

Machine learning and supercomputing have brought about a revolution in computational drug discovery. More therapeutic candidates, like antibodies that bind to and fight the SARS-CoV-2 virus, can be explored and simulated ...

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