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Cell & Microbiology Jul 5, 2023

Team develops new drug discovery platform

A highly versatile family of receptors found on the surface of our cells plays a massive role in the multibillion-dollar field of drug discovery. Called G protein-coupled receptors, or GPCRs, they also facilitate a staggering ...

Biochemistry Jun 28, 2023

Novel computational approach reveals previously inaccessible druggable pockets

A team of researchers from the Universities of Amsterdam and Zurich together with the Swiss company Allocyte Pharmaceuticals have for the first time been able to discover allosteric sites in a type of cell surface receptor ...

Biochemistry Jun 28, 2023

The potential of generative AI to accelerate antiviral development and drug discovery

In a new study, researchers from IBM, Oxford University and Diamond Light Source show that IBM's AI Model, MoLFormer, can generate antiviral molecules for multiple target virus proteins, including SARS-CoV-2, that can accelerate ...

Analytical Chemistry Jun 26, 2023

Towards synthesis of phenanthridine-based pharmaceutical compounds

Phenanthridines are heterocyclic compounds consisting of two six-membered benzene rings fused to a six-membered ring containing nitrogen. They are found in many naturally occurring organic compounds known for their anticancer ...

Molecular & Computational biology Jun 19, 2023

Scientists use supercomputer to detail HIV protein mechanism crucial for drug development

Every disease has a protein basis.

Analytical Chemistry Jun 19, 2023

Resolving hydrogen atoms in small organic molecules depending on chemical bond type

Extremely intense X-ray pulses can determine the positions of some hydrogen atoms in organic molecules that form small crystals, an all-RIKEN team has shown. Many areas, including drug discovery and materials research, stand ...

Condensed Matter Jun 16, 2023

Examining 'glitches in the matrix': Team finds ways to harness quantum power of atomic flaws

The most interesting parts of nature are often the imperfections. That's especially true in quantum physics, the atomic-level world where tiny flaws can make a big difference in the ways particles behave and interact.

Molecular & Computational biology Jun 8, 2023

New model offers a way to speed up drug discovery

Huge libraries of drug compounds may hold potential treatments for a variety of diseases, such as cancer or heart disease. Ideally, scientists would like to experimentally test each of these compounds against all possible ...

Biochemistry Jun 8, 2023

Mass spectrometry uncovers actions of protein 'glues'

A screening technique commonly used in drug discovery can yield important details about the actions of molecular 'glues' in protein interactions.

Quantum Âé¶¹ÒùÔºics Jun 8, 2023

How Schrödinger's cat makes better qubits

Quantum computing uses the principles of quantum mechanics to encode and elaborate data, meaning that it could one day solve computational problems that are intractable with current computers. While the latter work with bits, ...

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