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Search results for drug discovery

Molecular & Computational biology Jul 2, 2025

Researchers find 12 compounds that inhibit tuberculosis bacterium's energy source

A new study by University of Bath scientists has highlighted two new potential families of drug molecules that could open the door to new treatments for tuberculosis.

Biochemistry Jul 2, 2025

Flipping alkenes for more effective cancer drugs with fewer harmful side effects

For the first time, chemists have discovered a unique way to control and modify a type of compound widely used in medicines, including a drug used to treat breast cancer.

Condensed Matter Jul 2, 2025

AI predicts material properties using electron-level information without costly quantum mechanical computations

Researchers in Korea have developed an artificial intelligence (AI) technology that predicts molecular properties by learning electron-level information without requiring costly quantum mechanical calculations. The research ...

Cell & Microbiology Jul 2, 2025

Decades-old mystery solved: How Gram-negative bacteria keep their outer membrane intact

Researchers from the National University of Singapore (NUS) have solved a 60-year-old mystery in bacterial cell envelope biology, defining the primary function of an important protein complex responsible for maintaining the ...

Cell & Microbiology Jul 1, 2025

Modified inhibitors show promise against coronaviruses by targeting essential Mac1 protein domain

A study published in mBio details the vulnerability of coronaviruses to inhibitors of a small protein domain called Mac1, or the "macrodomain," found in all coronaviruses such as SARS-CoV-2 and MERS-CoV.

Biochemistry Jul 1, 2025

Novel cross-linker streamlines protein complex analysis in living cells

Proteins have specific biological functions in cells through conformational changes and interactions. Therefore, precise, in situ analysis of protein complex changes is essential for understanding cellular functions, uncovering ...

Biotechnology Jul 1, 2025

Multimodal method combines imaging and sequencing to study gene function in intact tissue

Imagine that you want to know the plot of a movie, but you only have access to either the visuals or the sound. With visuals alone, you'll miss all the dialog. With sound alone, you will miss the action. Understanding our ...

Biotechnology Jun 27, 2025

Light-powered microscopic swimmers with on/off control open new pathways for drug delivery

Scientists have created tiny disk-shaped particles that can swim on their own when hit with light, akin to microscopic robots that move through a special liquid without any external motors or propellers.

Biochemistry Jun 27, 2025

Beyond the crystal: Dynamic model captures loop flexibility in swine virus drug design

Porcine reproductive and respiratory syndrome virus (PRRSV) continues to devastate the global swine industry, yet the structural basis of how small molecules block its entry into host cells remains unclear. Researchers at ...

Biochemistry Jun 27, 2025

ColdBrew algorithm puts water to work in drug discovery

Every protein in the body is encased in a water shell that directs protein structure, provides vital stability and steers function. Because of this, water molecules represent a powerful but largely underappreciated foothold ...

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